|
科研队伍
郑天鹏 博士
郑天鹏，男，医学博士，教授，主任医师，桂林医学院杰出青年人才，内分泌与代谢专业优秀学术带头人，桂林医学院第二附属医院内分泌科副主任，广西糖尿病系统医学重点实验室副主任。从事内分泌与代谢专业的临床和科研工作，临床主要研究方向是糖尿病足的综合性诊疗，科研方面主要研究方向是糖尿病及其相关并发症的发生机制。迄今为止，以第一作者和（或）通讯作者身份共发表SCI论著27篇，累计影响因子169.5分，其中单篇IF>20分1篇，IF 10-20分3篇，包括内分泌与代谢领域顶级期刊Diabetes Care（IF：11.857）、JCEM以及相关领域知名杂志Psychotherapy and psychosomatics（IF：13.122）、The Journal of Clinical Psychiatry、Metabolism，Cardiovascular diabetology等，上述论文研究内容主要覆盖糖尿病、糖尿病肾病、糖尿病大血管病变、糖尿病性骨质疏松、糖尿病性认知功能障碍、糖尿病性抑郁等疾病的流行病学和发病机制研究。目前获得国家自然科学基金3项（面上项目1项，地区项目2项），广西自然科学基金1项，广西科学研究与技术开发计划1项。2015年度获得中华医学会糖尿病学分会授予的“2014年度中国糖尿病十大研究最具影响力研究奖”，2019年度获得广西青年科技奖，2024年获得“2023年广西自然科学一等奖”。指导硕士生13名，博士生2名。
近年发表论文：所有共同第一作者均加注上标“#”，通讯作者及共同通讯作者均加注上标“*”。
1.Hui Y#, Kuang L#, Zhong Y, Tang Y, Xu Z, Zheng T*. High glucose impairs cognitive function through inducing mitochondrial calcium overload in Treg cells. iScience. 2023 Dec 13;27(1):108689.
2.Li J#, Hui Y#, Xu Z#, Tan J, Yin K, Kuang L, Tang Y, Wei J, Zhou H, Zheng T*: Non-canonical Function of DPP4 Promotes Cognitive Impairment through ERp29-associated Mitochondrial Calcium Overload in Diabetes. iScience 2023;26(3): 106271.
3.Hui Y#, Xu Z#, Li J#, Kuang L, Zhong Y, Tang Y, Wei J, Zhou H, Zheng T*: Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization. Metabolism 2023;138:155340.
4.Sun C, Xiao Y, Li J, Ge B, Chen X, Liu H,Zheng T（郑天鹏）*. Nonenzymatic function of DPP4 in diabetes-associated mitochondrial dysfunction and cognitive impairment. Alzheimers Dement. 2021 Aug 10.
5.Tianpeng Zheng*,Xu Chen, Bo Ge, Bo Chen, Linyuan Qin,Li Tian , Yun Gao ,Xueping Hu, Liuping Xiao, Haidong Pan, Yujie Chen.Association between plasma dipeptidyl peptidase-4 activity to brain-derived neurotrophic factor ratio and depressive symptoms in middle-aged and older adults with normal glucose tolerance: A cross-sectional study.World J Biol Psychiatry. 2020 Oct;21(8):642-650.
6.Tianpeng Zheng*, Bo Ge, Linyuan Qin, Bo Chen, Li Tian, Yun Gao, Liuping Xiao, Xueping Hu, Haidong Pan, Yujie Chen.Association of Plasma DPP4 Activity and Brain-Derived Neurotrophic Factor With Moderate to Severe Depressive Symptoms in Patients With Type 2 Diabetes: Results From a Cross-Sectional Study.Psychosom Med.2020 May;82(4):350-358.
7.Xiao L,Ge B,Chen X,Chen B,Qin L,Hu X,Pan H,Chen Y,Tian L,Gao Y,Zheng T*.The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance. Front Aging Neurosci.2019 Mar 4; 11:33.
8.Zheng T*, Ge B, Liu H, Chen B, Qin L, Xiao L, Song J: Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China. Cardiovascular diabetology 2018;17:84
9.Yang L, Song J, Zhang X, Xiao L, Hu X, Pan H, Qin L, Liu H, Ge B, Zheng T*: Association of Serum Angiopoietin-Like Protein 8 With Albuminuria in Type 2 Diabetic Patients: Results From the GDMD Study in China. Frontiers in endocrinology 2018;9:414
10.Zheng T*, Liu H, Qin L, Chen B, Zhang X, Hu X, Xiao L, Qin S: Oxidative stress-mediated influence of plasma DPP4 activity to BDNF ratio on mild cognitive impairment in elderly type 2 diabetic patients: results from the GDMD study in China. Metabolism: clinical and experimental 2018;87:105-112
11.Zheng T*, Chen B, Yang L, Hu X, Zhang X, Liu H, Qin L: Association of plasma dipeptidyl peptidase-4 activity with non-alcoholic fatty liver disease in nondiabetic Chinese population. Metabolism: clinical and experimental 2017;73:125-134
12.Chen B#, Zheng T#*, Qin L, Hu X, Zhang X, Liu Y, Liu H, Qin S, Li G, Li Q: Strong Association between Plasma Dipeptidyl Peptidase-4 Activity and Impaired Cognitive Function in Elderly Population with Normal Glucose Tolerance. Frontiers in aging neuroscience 2017;9:247
13.Zheng T*, Qin L, Chen B, Hu X, Zhang X, Liu Y, Liu H, Qin S, Li G, Li Q: Plasma Dipeptidyl Peptidase-4 Activity, a Novel Biomarker or Even a Possible Therapeutic Target for Depression in Type 2 Diabetic Patients: Results from a Cross-Sectional Study in China. Psychotherapy and psychosomatics 2017;86:254-256
14.Zheng T*, Qin L, Chen B, Hu X, Zhang X, Liu Y, Liu H, Qin S, Li G, Li Q: Association of Plasma DPP4 Activity With Mild Cognitive Impairment in Elderly Patients With Type 2 Diabetes: Results From the GDMD Study in China. Diabetes care 2016;39:1594-1601
15.Zheng T, Liu Y, Qin S, Liu H, Zhang X, Zhao H: Increased plasma dipeptidyl peptidase-4 activities are associated with high prevalence of diabetic nephropathy in Chinese patients with newly diagnosed type 2 diabetes: A cross-sectional study. Diabetes & vascular disease research 2016;13:127-136
16.Zheng T*, Liu Y, Qin S, Liu H, Yang L, Zhang X, Li G, Li Q: Increased Dipeptidyl Peptidase-4 Activity Is Associated With High Prevalence of Depression in Middle-Aged and Older Adults: A Cross-Sectional Study. The Journal of clinical psychiatry 2016;77:e1248-e1255
获得基金：
1.DPP4非酶学功能介导的“代谢-免疫-神经”轴在2型糖尿病认知功能障碍中的作用及机制研究，国家自然科学基金地区项目。
2.高糖环境下认知功能障碍发生机制的基础研究，广西自然科学基金-杰出青年基金项目。
3.DPP4通过下调Foxp3基因表达抑制Treg细胞免疫调节作用的机制研究，国家自然科学基金地区项目。
4.DPP4非酶学功能介导的PAR2/GSK-3β/PGC-1α信号通路在2型糖尿病认知功能障碍中的作用及机制研究，国家自然科学基金面上项目。
5.糖尿病认知功能障碍的发病机制研究，桂林医学院杰出青年人才培养计划。
6.DPP4活性增高对血管内皮细胞功能影响及其机制研究，广西自然科学基金青年项目。
7.2型糖尿病高危人群规范化诊疗方案的建立及其卫生经济学评价，广西科学研究与技术开发计划。