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WANG Kai, YANG Huizhen

( Department of Rheumatology and Immunology , Digestive Districtl, the Second People'sHospital of Jiaozuo, Jiaozuo 454000,China)

AbstractObjective To observe the effect of different administration times of indomethacin on postoperativecomplications of endoscopic retrograde cholangiopancreatography ( ERCP ) for esophageal caneer. Methods 107esophageal caneer patients who underwent ERCP were randomly divided into two groups using a number tablemethod. 'T'he control group consisted of $3 patients who were received rectal injection of indomethacin for treatmentwithin 2 h alter surgery. The observation group consisted of 54 patients who were received preoperative rectalinjection of indomethacin for treatment, The postoperative complications, serum amylase( AMS ) levels,inflammatory reactions, and prognosis of the two groups of patients were compared. Results The incidenee of postoperative complications and AMS levels at 6 h, 12 h, and 24 h after surgery in the observation group were lowelthan those in the control group, and diference was statistically significant ( P<0.05); 1 d after surgery, lL-6, CRP'T'NF-a in the observation group were lower than the control group( P<0.05 ) ; the median progression-free surrival( PFS) and median overall surrival ( 0S ) of the observation group were higher than those of the control group, andthe mortality rate was lower than that of the control group ( P<0.05). Conclusion Preoperative rectal injection ofindomethacin combined with ERCP treatment can reduce the risk of postoperative complications in esophagealcaneer, inhibit the levels of various inflammatory indicators, and improve patient prognosis, which has a positive significance.

Keywords : esophageal caneer ; endoscopie retrograde cholangiopancreatography; indometacin ; inflammatory factors

DOI:10.19296/j.cnki.1008-2409.2024-02-020

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