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QIN Liling^a, KONG Lingping^a, LIN Xianjun^a, ZHAO Haiyun^a, LIN 

Gaojuan^b, MO Guixing^a

( a. Department of Otolaryngology, b. Department of Head and Neck 

Oncology, Nanxishan Hospital of Guangxi Zhuang Autonomous Regio, Guilin 541002, China)

Abstract Objective To explore the application value of plasma epstein barr-virus DNA ( EBV-DNA) combined with narrow-band imaging ( NBI) in monitoring the recurrence of nasopharyngeal carcinoma( NPC) . Methods 86 patients with recurrent NPC and 142 patients without recurrence were enrolled. The sensitivity, specificity, positive predictive value, negative predictive value, and consistency test ( Kappa value) of EBV-DNA, NBI, and EBV-DNA combined with NBI method in the diagnosis of NPC recurrence were observed. Receiver operating characteristic curve ( ROC) was used to analyze the area under the curve ( AUC) of EBV-DNA, NBI, and EBV-DNA combined with NBI for diagnosing NPC recurrence. Results ROC curve analysis results showed that the AUC of plasma EBV-DNA, NBI and combined diagnosis of NPC recurrence were 0.826, 0.845 and 0.893, respectively, and the AUC of plasma EBV-DNA combined with NBI was greater in predicting recurrence, with a statistically significance difference( P<0.05) . The stratified analysis showed that the AUC for predicting the recurrence of NPC in early and late patients was 0.924 and 0.865, and the Kappa value was 0.827 and 0.696. Conclusion In monitoring the diagnosis of NPC recurrence, the EBV-DNA combined with NBI method is more effective than a single method and is more effective in early-stage NPC patients. It is worthy of clinical application and promotion.

Keywords: nasopharyngeal carcinoma; recurrence monitoring; narrow-band imaging technology; epstein barr-virus DNA

DOI:10.19296/j.cnki.1008-2409.2024-03-020

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