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MU Zhijie¹, ZHANG Fan²

(1. Department of Gastroenterology, Wuzhi Jimin Hospital, Jiaozuo 454950, China;2. Department of Gastroenterology, Zhengzhou Second Hospital, 

Zhengzhou 450000, China)

Abstract Objective  To observe the clinical eicacy of amitriptyline in the treatment of irritable bowel syndrome( IBS). Methods 110 IBS patients were selected as the study subjects. They were randomly divided into two groupsusing a random number table method , with 55 patients in each group. The control group were received adjuvanttreatment with conventional dose of amitriptyline, while the experimental group were received low-dose amitriptylineas an adjuvant therapy. The treatment efficacy and safety were compared between two groups of patients. Results Atdifferent drug doses , the symptom scores of upper abdominal pain, abdominal burning, and decreased appetite in theexperimental group were slightly higher than those in the control group, and there was no statistically significant difference( P>0.05), while the levels of gastrin( GAS) , motlin( MLT) , pepsin I( PG I), and pepsin ¢ò ( PG ¢ò )were slightly lower than those in the control group ( P>0.05 ).The slow wave value after meals in the experimentalgroup was slightly lower than that in the control group, and the frequency and percentage of gastric electricaldisturbances were slightly higher than those in the control group ( P>0.05). The incidence of drug-related adversereactions in the experimental group was lower than that in the control group, showing a statistically significantdifference( P>0.05 ). Conclusion Amitriptyline can promote the recovery of related symptoms in IBS patients byenhancing gastric motlity and improving digestive function, and has a positive impact on improving the parameters ofthe patient's gastric electrogram. However, compared with conventional doses, low-dose amitriptyline has higher safety.

Keywords : irritable bowel syndrome ; amitriptyline ; gastrie motility; digestive function; drug safety

DOI:10.19296/i.cnki.1008-2409.2024-04-013

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