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JIN Ningchao¹, HU Qingqing², YANG Shuangjie²

( 1.Department of Pediatrics, the First People's Hospital of Xiangfu District, Kaifeng 475100.China:2.Department of Pediatrics, Kaifeng Children's Hospital, 

Kaifeng 475100.China)

Abstract Objective To investigate the clinical efficacy of the combination of recombinant human interferon ¦Á2b and acyclovir in the children with herpetic angina ( HA ) and its application value. Methods 108 children with HAwere retrospectively selected from January 2022 to December 2022 and divided into monotherapy group (n=54) andcombination group (n =54 ) according to different treatment. Methods The patients in the monotherapy group weretreated with acyclovir, and the patients in the combination group were treated with recombinant human interferon ¦Á2b combined with aeyclovir. The total effective rate, clinical symptoms disappearance time, adverse reactions.myocardial injury , inflammatory factor and immune funetion levels before and after treatment were compared between the monotherapy group and combination group. Results The total elfective rate in the combination group was 96.30% , which was higher than 85.19 % in the monotherapy group, showing a statistically significant difference ( P<0.05). After trentment for 7 d, the serum myocardial injury index, inflammatory factor level and CD3⁺ in thecombination group were lower than those in the monotherapy group, while immunoglobulin A ( IgA ), immunoglobulinG( IgG) , immunoglobulin M ( IgM ) and CD4⁺ in the combination group were higher than those in the monotherapygroup ( P<0.05 ). The incidenee of adverse reactions in the combination group was 9.26%. which was no statisticallsignificant compared with 5.56% in the monotherapy group ( P>0.05 ). Conclusion Recombinant human interferon ¦Á2b combined with acyclovir is ellective therapy in children with HA, which accelerates the process ofrehabilitation , alleviates elfectively the clinical symptoms , improves the myocardial injury , inhibits the inammatoryresponse , and enhances the immune function.

Keywords : herpetic angina ; recombinant human interferon ¦Á2b; acyclovir; inflammatory factors ; myocardial injury

DOI:10.19296/j.cnki.1008-2409.2024-04-028

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