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LIANG Yuan^a, WANG Jiajia^b

(a. Department of Endocrinology, b. Department of Traditional Chinese 

Medicine ,the First People's Hospital of Nanyang, Nanyang 473000,China)

Abstract Objective To analyze the relationship between Clq tumor necrosis factor related protein 3 ( CTRP3 ) andthe level of bone metabolism and to analyze the predictive efficacy of CTRP3 for fracture risk in type 2 diabetesmellitus ( T2DM ) patients. Methods 121 T2DM patients were selected. The patients were divided into the lowCTRP3 level group ( CT'RP3<300 ng/mL, 63 cases) and the high level group ( CTRP3>300 ng/mL, 58 cases)The relationship between CTRP3 level and bone metabolism indicators was analyzed. The risk factors of T2DM fractures were analyzed and the predictive efficacy of CTRP3 on fracture risk was verified. Results The bone density.the level of osteoprotegerin ( 0PG) and bone specific alkaline phosphatase ( BALP) in the low CTRP3 level groupwere significantly lower than those in the high CTRP3 level group ( P<0.05). The levels of type 1 collagen at the C.terminus ¦Â Special sequence ( ¦Â-CTX) in the low C'T'RP3 level group was significantly higher than that in the highC'TRP3 level group ( P<0.05). The expression of CTRP3 was positively correlated with bone density, the level of OPG was negatively correlated with the level of BALP and ¦Â-CTX, The levels of CTRP3, OPG and BALP and bonedensity in the fracture group were significantly lower than those in the non fracture group, the levels of ¦Â-CTX in thefracture group was significantly higher than that in the non fracture group ( P<0.05). CTRP3, bone density, OPG.BALP B-CTX were the risk factor for fractures in T2DM patients . CTRP3 had a high predictive efficaey for fracturerisk in T2DM patients. Conclusion CTRP3 is closely related to the bone metabolism level in T2DM patients, and CTRP3 expression levels can early predict the fracture risk.

Keywords: type 2 diabetes mellitus; bone metabolism; Clq tumor necrosis factor related protein 3; fracture ;predictive perormance

DOI:10.19296/i.cnki.1008-2409.2024-04-021

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