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WANG Yan, CHEN Shuoguang, WANG Juan, CHEN Xu

(College of Pharmacy, Guilin Medical University, Guilin 541199, China)

Abstract (bjective To investigate the protective effeets of leonurine against acute alcohol-induced liverinjury. Methods The experimental design involved the random allocation of C57BL/6J mice into fivegroups: control group, model group, low-dose leonurine group, high-dose leonurine group, and Bifendategroup, with 8 mice in each group. The leonurine and Bifendate groups were received their designatd dosesthrough oral gavage onee daily for a continuous period of 10 d. In contrast, the control and model groups were given an equivalent volume of saline solution during the same timeframe. 12 h after the final dose . algroups except the control were given 56% alcohol content Beijing Erguotou by oral gavage for threeconsecutive days, with a 12-hour interval between each administration. After the final administration ofBeijing Erguotou, the mice were fasted for 4 h before euthanasia, and their livers were weighed to calculatethe liver coefficient. Serum levels of alanine aminotransferase ( ALT'), aspartate aminotransferase ( AST )triglyeerides ( TG ), and malondialdehyde ( MDA) were measured, Hepatic pathological changes wereobserved via hematoxylin-eosin staining, and relevant proteins were detected by Western blot. Results Inthe model group , levels of ALT, AST, TG , MDA, and liver indices were significantly higher compared tothe control group, with a statistically significant differenee ( P<0.05 ). The levels of ALT, AST, TG, MDAin both low-dose and high-dose leonurine groups were lower than those in the model group ( P<0.05 ).Hepatic pathologieal examination and Oil Red 0 staining indicated that leonurine reduced ethanol-inducedliver tissue damage in mice( P<0.05). Conclusion leonurine demonstrates a protective effeet against acutealeohol-induced liver injury.

Keywords: acute alcohol-induced liver injury; leonurine; alcohol; liver injury protection

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