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DONG Shiying ^1¢Ù , WANG Peipei ² , ZHANG Lu ¹

(1. Dept. of Anesthesiology, Xuchang Hospital of Traditional Chinese Medicine, Xuchang 461000; 2. Dept.of Anesthesiology, Beihai Hospital of Xuchang, Xuchang 461000, China)

Abstract Objective: To investigate the effect of low-dose propofol (P) combined with lumbar sciatic plexus nerve block (L-SPNB) on the hemodynamics in elderly patients with femoral intertrochanteric fracture (FIF). Methods:123 elderly patients with FIF were selected and randomly divided into twogroups. 61 patients in group A received general anesthesia, while group B received the anesthesia of L-SPNB combined with P. The blocking effect, hemodynamics, stress response condition and cognitive function of the two groups were compared. Results: There were no significant differences in OAA/ S scores of both groups at T1 (P>0.05); OAA/ S scores of group B were lower than those of group A at T2, with a statistically significant difference (P<0.05).The heart rate (HR) and mean arterial pressure (MAP) in group B were lower than that in group A at T1 and T2 (P<0.05). The serum noradrenaline (NE) and cortisol (Cor) in group B were lower than those in group A (P<0.05) at T1 and T2. One day and three days after operation, the Montreal Cognitive Assessment (MoCA) and the Mini-mental State Examination (MMSE) in group B were all higher than those in group A (P<0.05). Conclusion: The block effect of low-dose P combined with L-SPNB is confirmed by significantly effects of intravenous general anesthesia, and it has less effect on hemodynamics during operation of patients with FIF.

Keywords: low-dose propofol; lumbar sciatic plexus nerve block; stress response; femoral intertrochanteric fracture in the elderly

DOI:10.19296/ j.cnki.1008-2409.2023-01-008

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