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FAN Hongli ¢Ù , REN Lili, LI Xiuwei

(Dept. of Radiotherapy, the Central Hospital of Zhoukou, Zhoukou 466000,

 China)

Abstract Objective: To investigate the effects of intensity-modulated radiotherapy (IMRT) combined with nedaplatin in patients with cervical cancer. Methods: 84 patients with cervical cancer were randomized into two groups, each with 42 patients. The control group received IMRT, while the study group were treated with IMRT combined with nedaplatin. The total effective rate, disease control rate, levels of tumor marker and miRNA, adverse reactions and long-term efficacy were compared between the two groups. Results: The total effective rate of the study group was 83.33 % , higher than 64.29 % of the control group, the difference was statistically significant (P<0.05); the disease control rate was 92.86 % in the study group, higher than 71.69 % in the control group (P<0.05); after treatment, levels of serum tumor marker AFP,CK19, CA125, chemer in of the study group were lower than those of the control group (P<0.05); after treatment, levels of serum miR-130b-5p and miR-142-5p of the study group averaging lower than those of the control group (P<0.05); There was no significant difference in the incidence of adverse reactions during treatment and one-year survival rate after treatment between the two groups (P>0.05); and the distant metastasis and local recurrence rate in the study group was lower than that in the control group for one-year follow-up ( P < 0. 05). Conclusion: IMRT combined with nedaplatin has gained remarkable effect on patients with cervical cancer, which can lower the serum tumor marker level, regulate miRNA expression and reduce the risk of recurrence and metastasis in patients.

Keywords: nedaplatin; intensity-modulated radiotherapy; cervical cancer; tumor marker

DOI:10.19296/ j.cnki.1008-2409.2023-01-011

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