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JIN Ningchao¹, HU Qingqing², YANG Shuangjie²

(1. Department of Pediatrics, the First People¡äs Hospital of Xiangfu District, 

Kaifeng 475100,China; 2. Department of Pediatrics, Kaifeng Children¡äs Hospital, Kaifeng 475100, China)

Abstract Objective To investigate the clinical value of acetylcysteine combined with hydrocortisone in the treatment of mycoplasma pneumonia of children. Methods 116 children with mycoplasma pneumonia were retrospectively analyzed, and they were divided into the control group and the study group, with 58 cases in each group. Both groups were given sequential azithromycin therapy, on the basis of which the control group were given hydrocortisone treatment, and the study group were given acetyl cysteine combined with hydrocortisone treatment. The curative effect and symptom improvement were compared between the two groups. The levels of T cell subsets, serum inflammatory indicators and adverse reactions were compared between the two groups before and 7 d after treatment. Results The total response rate of the study group was higher than that of the control group, with a statistically significant difference ( P < 0.05) . The symptom improvement time in the study group was shorter than that of the control group ( P<0.05) . CD3+ , CD4+/CD8+ were higher than the control group and CD8+ was lower than the control group ( P<0.05) . The levels of C-reactive protein, interleukin-6, TNF-¦Á in the study group were lower than the control group ( P<0.05) . There was no statistically significant difference in the total incidence of adverse reactions between the study group and the control group ( P>0.05) . Conclusion Acetylcysteine combined with hydrocortisone in the treatment of mycoplasma pneumonia of children has significant effects on improving inflammation, improving immunity, relieving clinical symptoms, and is safe and reliable.

Keywords: acetylcysteine atomizing solution; hydrocortisone succinate; mycoplasma pneumonia; T cell subpopulation; inflammatory response

DOI:10.19296/j.cnki.1008-2409.2024-03-011

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