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WEN Xiaoyi, QIU Yingting, LIU Xi, SU Yingchun, XIAO Rong, QI Yanping

( Pingxiang Maternity and Child Care, Pingxiang 337000, China)

Abstract Objective To investigate the effects of low-molecular-weight heparin ( LMWH ) applied to improve uterine arterial resistance to blood flow in frozen-thawed embryo cycles on pregnancy outcomes in patients with polycystic ovary syndrome ( PCOS) . Methods 83 patients with PCOS were divided into a control group (40 cases) and an observation group (43 cases) based on whether LMWH was used during freeze-thaw embryo transfer ( FET) . Endometrial blood flow-related indexes of pulsatility index ( PI ) , resistance index ( RI ) , ratio of end-systolic to end-diastolic blood flow velocity ( S/D ) , pregnancy outcome and adverse reactions were analyzed in the two groups. Results After treatment, the endometrial blood flow PI, RI and S/D of the observation group were lower than those of the control group, and the embryo implantation rate as 66. 23% was higher than that of the control group as 48. 61%, with a statistically significant difference ( P<0.05) ; the rate of early miscarriage was lower than that of the control group as 5.71%,which was lower than that of the control group as 28.57% ( P<0.05) ; the comparison of the rates of clinical pregnancy and the incidence of adverse reactions of the two groups did not have a statistically significant difference ( P>0.05) . Conclusion Application of LMWH therapy in frozen-thawed embryo cycles improves uterine arterial blood flow, increases embryo implantation rates, and improves pregnancy outcomes in patients with PCOS.

Keywords: polycystic ovary syndrome; low-molecular-weight heparin; frozen-thawed embryo cycles; pregnancy outcome

DOI:10.19296/j.cnki.1008-2409.2024-03-025

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