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OU Xiang^1a,LIU Lisha^1b,TANG Shilin², SHAO Huige^1a

(1. a. Department of Endocrinology, b. Clinical Laboratory, the Affiliated 

Changsha Central Hospital,Hengyang Medical School, University of South 

China,Changsha 410004, China; 2. Department of Intensive Care Unit, the 

First Affiliated Hospital of University, Hengyang Medical School, University of South China, Hengyang 421001, China)

Abstract Objective To investigate the risk factors of corona virus disease 2019 ( COVID-19) infection in patients with type 2 diabetes mellitus ( T2DM) . Methods 78 T2DM patients without COVID-19 and 24 T2DM patients with COVID-19 were selected. Age, body mass index, duration of diabetes, systolic blood pressure, diastolic blood pressure, blood lipids, white blood cell count, neutrophil count, fasting glucose, 2 h postprandial glucose, fasting C-peptide, 2 h postprandial C-peptide, glycated hemoglobin, and ¦Â- hydroxybutyrate were compared, and the correlations between the above factors and COVID-19 infection were analyzed. Results The level of total cholesterol in the infected group was significantly lower than that in the uninfected group. The difference was statistically significant ( P<0.05) . The levels of HbA1c and ¦Â- hydroxybutyric acid in T2DM patients with COVID-19 were significantly higher than those in T2DM patients without COVID-19 ( P<0.05) . Spearman correlation analysis showed that COVID-19 infection was positively correlated with fasting glucose, glycated hemoglobin, systolic blood pressure, and ¦Â- hydroxybutyrate ( P < 0. 05) and COVID-19 infection was negatively correlated with total cholesterol and postprandial 2 h C-peptide ( P < 0. 05) . Logistic regression analysis revealed that total cholesterol and glycated hemoglobin were important influencing factors of T2DM patients with COVID-19 infection ( P < 0.05) . Conclusion Elevated fasting glucose, glycated hemoglobin, systolic blood pressure, and ¦Â- hydroxybutyrate levels, as well as decreased total cholesterol and 2 h postprandial C-peptide levels, may be risk factors for the infection of COVID-19 in patients with T2DM, and control of related factors can reduce the risk of COVID-19 infection in patients with T2DM.

Keywords: type 2 diabetes mellitus; corona virus disease 2019; risk factor

DOI:10.19296/j.cnki.1008-2409.2024-03-034

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