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WU Genggang

( Department of Breast Surgery,the Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou 511300, China)

Abstract Objective To investigate the expression level of miR-150-5p in tissues and serum of thyroid cancer tissues and to explore its auxiliary value for differential diagnosis of thyroid cancer. Methods 82 cases of thyroid cancer patients were selected ( pathology group) , and 82 cases of healthy people with physical examination were selected and set as the control group. The miR-150-5p expressions in the tissue and serum of thyroid cancer patients were compared, and the relationship between the miR-150-5p expressions in tissue and serum and the clinical characteristics of thyroid cancer patients was analyzed. Results The miR-150-5p expression level in thyroid cancer tissues was lower than that in paraneoplastic tissues, showing a statistically significant difference( P<0.05) . Serum miR-150-5p level in the case group was lower than that in the control group ( P < 0. 05 ) . Comparison of tissue and serum miR-150-5p expression levels in patients with different clinical stages, differentiation degrees, lymph node metastasis, and tumor diameter conditions showed statistically significant differences ( P < 0. 05) . Tissue miR-150-5p expression was significant negative correlation ( P < 0.05) with clinical stage ( rs = - 0.497) , lymph node metastasis ( rs = -0.315) , and tumor diameter ( rs = -0.444) . The miR-150-5p expression was significant positive correlation ( P<0.05) with differentiation degree ( r = 0.404) . Serum miR-150-5p expression was significant negative correlation ( P<0.05) with clinical stage ( rs = -0.455) , lymph node metastasis ( rs = -0.306) , and tumor diameter ( rs = - 0. 433 ) . The miR-150-5p expression was significant positive correlation ( P< 0.05) with degree of differentiation ( rs = 0.420) . Conclusion The miR-150-5p shows low expression in tissue and serum of thyroid cancer, which is closely correlated with clinical stage, degree of differentiation, lymph node metastasis, and tumor diameter.

Keywords: thyroid cancer; miR-150-5p; expression; forecast

DOI:10.19296/j.cnki.1008-2409.2024-03-035

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