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ZHANG Rui, FU Yanan, LIU Yulu

( Neonatal Intensive Care Unit, the First People's Hospital of Shangqiu City, Shangqiu 476000, China)

Abstract Objective To investigate the ellects of caffeine citrate injection combined with calf pulmonary surfactant( CPS) on tidal respiratory lung function and serum oxidative stress indexes in neonatal respiratory distress syndrome( NRDS ). Methods 74 children with NRDS were seleeted and divided into the control group ( treated with CPS) andobservation group ( treated with caffeine citrate injection combined with CPS ) according to the treatment plan. Theclinical efficacy , blood gas analysis indicators before and after treatment, tidal respiratory lung function indicators.serum oxidative stress indicators, E-selectin( CD62E ) levels, and incidence of complications were compared between two groups. Results The total clinical effective rate of the observation group was higher than that of thecontrol group, showing a statistically significant difference( P<0.05 ). After 7 d of treatment, PaO, and PaCO, inobservation group were higher than those in the control group ( P<0.05). After 7 d of treatment, the observationgroup had a higher time to peak tidal expiratory flow as a proportion of expiratory time( TPTEF/TE ) , tidal volume( VT), and peak volume ratio ( VPEF/VE) compared to the control group, while the respiratory rate ( RR ) waslower than the control group ( P<0.05 ). After 7 d of treatment, the observation group had a higher TPTEF/TE , V'Tand peak volume ratio( VPEF/VE ) compared to the control group, while the RR was lower than the control group( P<0.05 ). There was no statistically significant difference in the total incidence of complications between the twogroups( P>0.05 ) .Conclusion Cafleine citrate combined with CPS can elfectively promote the improvement of bloodgas analysis indexes, lung function, relieve oxidative stress-inflammation state, improve efficacy and safety in children with NRDS.

Keywords : caffeine citrate injection; calf pulmonary surfactant; neonatal respiratory distress syndrome; tidalrespiration lung function; oxidative stress

DOI:10.19296/i.cnki.1008-2409.2024-04-014

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