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LI Li ,ZHAO Huixin ,YUAN Xiaomin

(Department of Obstetrics and Gynecology, Nanyang Hospital of Traditional Chinese Medicine)

Abstract Objective To analyze the therapentic effect of Goserelin combined with hysteroscopic electroresection in the treatment of patients with early endometrial cancer. Methods 83 patients with earlyendometrial cancer were selected and grouped by random number table method. The patients in control group(41 cases) were received hysteroscopic electroresection, and the patients in observation group(42 cases) were received Goserelin combined with hysteroscopic electroresection. The therapeutic effect between the two groups was compared. Results The remission rate of disease in observation group was significantly higher than that in control group(P< 0.05). After treatment, the levels of tumor related factors were significantly decreased in both groups, and the levels of serum carbohydrate antigen125(CA125), human epididymal secretory protein 4(HE4)and placental growth factor(PLGF)in observation group were significantly lower than those in control group(P<0.05). After treatment, the serum leveIs of follicle-stimulating hormone(fSH), estradiol(E2)and luteinizing hormone(LH)in two groups were significantly changed compared with pre-treatment, and the observation group was better than the control group(P<0.05). The successful pregnancy rate and full-term productivity in the observation groupwere significantly higher than those in the control group(P<0.05), but there was no significant difference in the rates of premature birth and abortion between the two groups(P>0.05). After treatment, theQLQ-C30 score in the observation group was significantly lower than that in the control group(P<0.05). Conclusion Goserelin combined with hysteroscopic resection improves the clinical efficacy of early edometrial cancer, reduces the level of tumor factors, protects ovarian function and improves the success rate of pregnancy.

Key words: Goserelin ; hysteroscopic electroresection ; early endometrial cancer ;tumor-related factors : ovarian function

DOI:10.19296/i.cnki.1008-2409.2024-04-020

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