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WANG Kai^a,GUO Airong^a, WANG Yan^b

( a.Department of Blood Transfusion , b. Department of Laboratory, Nanyang Second People's Hospital.Nanyang 473000,China)

Objective To explore the predictive value of serum platelet count ( PLT), insulin-like growth factorAbstractbinding protein-3 ( IGFBP-3) and albumin ( ALB ) levels for upper gastrointestinal bleeding ( UGH) in patients withcirthosis. Methods 136 patients with cirhosis were selected and divided into the bleeding group ( 43 cases) andnon-bleeding group (93 cases) based on the presence or absenee of UGH after treatment. The levels of serum PITIGFBP-3 and ALB were compared between the two groups of patients with different grades of cirhosis, and the correlation and predictive value were analyzed. Results The levels of PLT, ALB and type IV collagen in thehemorrhagic group were lower than those in the non-hemorhagic group, while the levels of serum IGFBP-3 andlaminin and hyaluronic acid were higher than those in the non-hemorrhagic group, showing a statistically significantdifference ( P<0.05 ). Comparing the levels of serum PLT, ALB and type IV collagen in different Child-Pugh grades(A, B and C) in the hemorhagic group showed that A grade>B grade>C grade, serum IGFBP-3 level, lamininwhile hyaluronic acid showed that C grade>B grade>A grade ( P<0.05 ). Laminin, hyaluronic acid, and Child-Pughgrade were negatively correlated with serum PLT, ALB and and positively correlated with serum IGFBP-3. The levelof type IV collagen is positively correlated with serum PLT and ALB, and negatively correlated with serum IGFBP-3(P<0.05). The AUC of the combined prediction of serum PLT, IGFBP-3 and ALB levels was greater than that ofeach individual indicator. Conclusion The combined prediction of serum PLT, IGFBP-3 and ALB levels provides areliable basis for clinical evaluation of UGH in patients with cirrhosis.

Keywords:platelet count;insulin-likegrowth factor binding protein-3;albumin;uppergastrointestinahemorrhagic ;predictive value : correlation

DOI:10.19296/i.cnki.1008-2409.2024-04-022

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